منابع مشابه
Comparing Genomes
s new ways of using biological material to solve difficult computational problems continue to emerge, several fundamental questions arise: Are these techniques practical? If so, what are the key appli-cations? Do the techniques scale to larger prob-lems? Do they give us anything more than a few elegant theoretical insights into the nature of com-putation? Ultimately, is this a productive endeav...
متن کاملComparing genomes within the species Mycobacterium tuberculosis.
The study of genetic variability within natural populations of pathogens may provide insight into their evolution and pathogenesis. We used a Mycobacterium tuberculosis high-density oligonucleotide microarray to detect small-scale genomic deletions among 19 clinically and epidemiologically well-characterized isolates of M. tuberculosis. The pattern of deletions detected was identical within myc...
متن کاملComparing genomes with rearrangements and segmental duplications
MOTIVATION Large-scale evolutionary events such as genomic rearrange.ments and segmental duplications form an important part of the evolution of genomes and are widely studied from both biological and computational perspectives. A basic computational problem is to infer these events in the evolutionary history for given modern genomes, a task for which many algorithms have been proposed under v...
متن کاملBugView: a browser for comparing genomes
UNLABELLED BugView is a Java application for visualizing homologous genes on a pair of related genomes, and can also be used to view individual genomes. It accepts files of prokaryotic or eukaryotic genomes in GenBank format and allows users to assign homologous pairs, and make and save annotations. AVAILABILITY http://www.gla.ac.uk/~dpl1n/BugView/
متن کاملA Method for Comparing Three Genomes
The large amount of data from complete genomes gave rise to the need for computational tools to analyze and compare them. In this work, we propose a method for comparing three genomes simultaneously, at the basic level of their sequences. This comparison can indicate the set of genes shared by genomes, giving interesting clues about the metabolic pathways and proteins related to particular issu...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2002
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20020617-01